Sunday, December 13, 2009

The Future of Aging: Pathways to Human Life Extension

See also:
-- 'Longevity Science' blog
-- 'Health Studies' blog


Here is a new upcoming book for discussion (click on the book title below for more detail):

The Future of Aging: Pathways to Human Life ExtensionEditor-in-chief: Dr. Gregory M. Fahy
Springer, May 4, 2010
Approx. 500 p., Hardcover
ISBN: 978-90-481-3998-9

This new book (about 500 pages) is written by a team of 40 experts.

Book Description provided by the Publisher (Springer):

Just as the health costs of aging threaten to bankrupt developed countries, this book makes the scientific case that a biological "bailout" could be on the way, and that human aging can be different in the future than it is today.

Here 40 authors argue how our improving understanding of the biology of aging and selected technologies should enable the successful use of many different and complementary methods for ameliorating aging, and why such interventions are appropriate based on our current historical, anthropological, philosophical, ethical, evolutionary, and biological context.

Challenging concepts are presented together with in-depth reviews and paradigm-breaking proposals that collectively illustrate the potential for changing aging as never before. The proposals extend from today to a future many decades from now in which the control of aging may become effectively complete.

Examples include sirtuin-modulating pills, new concepts for attacking cardiovascular disease and cancer, mitochondrial rejuvenation, stem cell therapies and regeneration, tissue reconstruction, telomere maintenance, prevention of immunosenescence, extracellular rejuvenation, artificial DNA repair, and full deployment of nanotechnology.

The Future of Aging will make you think about aging differently and is a challenge to all of us to open our eyes to the future therapeutic potential of biogerontology.

Written for:

Biogerontologists and physicians and politicians concerned with issues associated with aging; educated laypeople trying to see the future direction of aging as it may pertain to their own lives; potential use as a teaching tool in graduate level courses about the biology of aging; biomedical research and university libraries that maintain collections related to gerontology.

Key words:
New books, Future of Aging, Life Extension, Greg Fahy, Springer, Aging, Ageing, Gerontology,

Do you have any comments on this new book?
Post them below by clicking here!

Table of contents

Part 1: Introduction and Orientation;

Chapter 1
Bridges to Life
Ray Kurzweil, Kurzweil Technologies, Inc. Wellesley, MA, and Terry Grossman, M.D., Frontier Medical Institute, Denver, CO

Chapter 2
Analyzing Predictions: An Anthropological View of Anti-Aging Futures
Courtney Everts Mykytyn, Ph.D., Department of Anthropology, University of Southern California, Los Angeles, CA, USA

Chapter 3
Towards Naturalistic Transcendence: The Value of Life and Life Extension to Persons as Conative Processes
Steven Horrobin, Ph.D., College of Medicine, University of Edinburgh, Scotland, UK

Chapter 4
The Ethical Basis for Using Human Embryonic Stem Cells in the Treatment of Aging
L. Stephen Coles, M.D., Ph.D., David Geffen School of Medicine, UCLA, Los Angeles, CA, USA

Chapter 5
Evolutionary Origins of Aging
Joshua Mitteldorf, Ph.D., Dept of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ

Chapter 6
Precedents for the Biological Control of Aging: Experimental Postponement, Prevention, and Reversal of Aging Processes
Gregory M. Fahy, Ph.D., Intervene Biomedical, Norco, CA, USA

Part 2: The Future of Aging

Chapter 7
An Approach to Extending Healthspan and Lifespan Today
Chris Heward, Ph.D., President, Kronos Science Laboratory, Phoenix, AZ, USA

Chapter 8
Near-Term Prospects for Amelioration of Cardiovascular Aging
Roger Yu, M.D., Beth Israel Deaconess Medical Center, Boston, MA 02215, and Mohammad Navab, Ph.D., David Geffen School of Medicine, UCLA, Los Angeles, CA, USA

Chapter 9
Near Term Prospects for Broad Spectrum Amelioration of Cancer
Zheng Cui, Ph.D., Wake Forest University School of Medicine, inston-Salem, NC, USA

Chapter 10
Small Molecule Modulators of Sirtuin Activity
Francisco J. Alcain, Ph.D., Robin K. Minor, Ph.D., Jose M. Villalba, Ph.D., Departamento de Biologнa Celular, Fisiologнa e Inmunologнa, Universidad de Cуrdoba, Cуrdoba, Spain, and Rafael de Cabo, Ph.D., Laboratory of Experimental Gerontology, National Institute on Aging, NIH, Baltimore, MD, USA

Chapter 11
Evolutionary Nutrigenomics
Michael Rose, Ph.D., Anthony D. Long, Ph.D., Laurence D. Mueller, Ph.D.,Cristina L. Rizza, Ph.D., Kennedy C. Matsagas, Ph.D.,Lee F. Greer, Ph.D., and Bryant Villeponteau, Ph.D.Genescient, LLC, Irvine, CA, USA

Chapter 12
Biological Effects of Calorie Restriction:Implications for Modification of Human Aging
Stephen R. Spindler, Ph.D., Department of Biochemistry,University of California at Riverside, Riverside, CA, USA

Chapter 13
Calibrating Notch/TGF-Я Signaling for Youthful, Healthy Tissue Maintenance and Repair
Morgan E. Carlson, Ph.D. and Irina M. Conboy, Ph.D., Department of Bioengineering, University of California, Berkeley, CA, USA

Chapter 14
Embryonic Stem Cells:Prospects of Regenerative Medicine for the Treatment of Human Aging
Mike West, Ph.D., Chief Scientific Officer, BioTime, Inc., and Embryome Sciences, Inc., Alameda, CA, USA, and Adjunct Professor, University of California at Berkeley, Berkeley, CA, USA

Chapter 15
Maintenance and Restoration of Immune System Function
Richard Aspinall, Ph.D., and Wayne Mitchell, Ph.D., School of Medicine, Division of Investigative Science,Imperial College London, London, UK

Chapter 16
Mitochondrial Manipulation as a Treatment for Aging
Rafal Smigrodzki, M.D., and Francisco R. Portell, B.S., Gencia, Inc., Charlottesville, VA, USA

Chapter 17
Life Extension by Tissue and Organ Replacement
Anthony Atala, M.D., Director, Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA

Chapter 18
Telomeres and the Arithmetic of Human Longevity
Abraham Aviv, M.D., and John D. Bogden, Ph.D., The Center of Human Development and Aging, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ, USA

Chapter 19
Repairing Extracellular Aging and Glycation
John Furber, C.E.O., Legendary Pharmaceuticals, Inc., Gainesville, FL USA

Chapter 20
Methuselah’s DNA: Defining Genes that Can Extend Longevity
Robert J. Shmookler-Reis, Ph.D., and Joan McEwen, Ph.D. , VA Medical Center, University of Arkansas for Medical Science, Little Rock, AR, USA

Chapter 21
Reversing Age-Related DNA Damage through Engineered DNA Repair
Clifford Steer, M.D., Director, Molecular Gastroenterology Program, and Betsy Kren, Ph.D., Department of Medicine, GI Division, University of Minnesota Medical School, Minneapolis, MN, USA

Chapter 22
WILT: Necessity, Feasibility, Affordability
Aubrey de Grey, Ph.D., Methuselah Foundation, Lorton, VA, USA

Chapter 23
Comprehensive Nanorobotic Control of Human Morbidity and Aging
Robert A. Freitas, Jr., J.D., Institute for Molecular Manufacturing, Palo Alto, CA, USA

Appendices: Two Unusual Potential Sources of Funding for Longevity Research

Appendix I: The SENS Foundation: Accelerating Progress toward Biomedical Rejuvenation, Michael Rae, SENS Foundation, Redwood City, CA, USA

Appendix II: The Manhattan Beach Project, David Kekich, CEO, Maximum Life Foundation, Inc., Los Angeles, CA, USA


The Future of Aging: Pathways to Human Life Extension
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